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Article

Methylation and colorectal cancer

1 Jan 2001

Abstract excerpt

Statistics rate colorectal adenocarcinoma as the most common cause of cancer death on exclusion of smoking-related neoplasia. However, the reported accumulation of genetic lesions over the adenoma to adenocarcinoma sequence cannot wholly account for the neoplastic phenotype. Recently, heritable, epigenetic changes in DNA methylation, in association with a repressive chromatin structure, have been identified as...

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PMID: 11568897
DOI: 10.1002/path.923

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