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Article

Robust multipoint identical-by-descent mapping for affected relative pairs.

American journal of human genetics - 1 Jan 2005

Schaid Daniel J, Sinnwell Jason P, Thibodeau Stephen N

Abstract excerpt

The genetic mapping of complex traits has been challenging and has required new statistical methods that are robust to misspecified models. Liang et al. proposed a robust multipoint method that can be used to simultaneously estimate, on the basis of sib-pair linkage data, both the position of a trait locus on a chromosome and its effect on disease status. The advantage of their method is that it does not require...

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Identifiers

PMID: 15573301
DOI: 10.1086/427343
PMCID: PMC1196415

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