Article
A robust multipoint linkage statistic (tlod) for mapping complex trait loci.
Genetic epidemiology - 1 Jan 2001
Abkevich V, Camp N J, Gutin A, Farnham J M, Cannon-Albright L, Thomas A
Abstract excerpt
Classical parametric two-point linkage analysis is a powerful analysis tool, however there are clear disadvantages too, including the sensitivity to allele frequency mis-specification. Conversely, multipoint linkage analysis is not sensitive to allele frequency mis-specification, but it is sensitive to genetic model mis-specification. Göring and Terwilliger [Am J Hum Genet 66:1095-106, 2000] proposed a new robust...
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