Article
The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development.
The Journal of biological chemistry - 18 Feb 2005
Campbell Sandra J, Henderson Colin J, Anthony Daniel C, Davidson Duncan, Clark A John, Wolf C Roland
Abstract excerpt
In adult mice the cytochrome P450 Cyp1a1 gene is not constitutively expressed but is highly inducible by foreign compounds acting through the aryl hydrocarbon (Ah) receptor. However, the expression profile of the Cyp1a1 gene in the developing embryo is not well under-stood. Using established transgenic mouse lines where 8.5 kb of the rat CYP1A1 promoter is cloned upstream of the lacZ reporter gene (1), we...
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