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Article

Mutation of mouse Cyp11a1 promoter caused tissue-specific reduction of gene expression and blunted stress response without affecting reproduction.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2008

Shih Meng-Chun, Hsu Nai-Chi, Huang Chen-Che, Wu Tzong-Shoon, Lai Pao-Yen, Chung Bon-Chu

Abstract excerpt

Steroids are synthesized mainly from the adrenal glands catalyzed by steroidogenic enzymes; the expression of these enzymes is controlled by transcription factor steroidogenic factor-1 (SF-1; NR5A1). To understand the physiological effect of genetic changes on steroid secretion, we used Cre-LoxP and gene targeting technology to mutate the binding sequence for SF-1 (SF-1 response element) on the promoter of the...

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Identifiers

PMID: 18174359
DOI: 10.1210/me.2007-0222
PMCID: PMC5419550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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