Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genetic analysis of processes regulating cytochrome P4501A1 expression.

Advances in enzyme regulation - 1 Jan 1994

Hankinson O

Abstract excerpt

Cytochrome P4501A1 and its associated aryl hydrocarbon hydroxylase activity are highly inducible in the mouse hepatoma cell line, Hepa-1, by substrates of the enzyme and related compounds, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mutants of this cell line, deficient in P4501A1 inducibility, were isolated. Some of the mutants show a dominant phenotype. Such mutants may have resulted from a genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cloning, Molecular
Share to Genes
Share to Genetic Complementation Test

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Transfection

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 7942273
DOI: 10.1016/0065-2571(94)90015-9

Genes

ARNT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genetic analysis of processes regulating cytochrome P4501A1 expression.PMID 7942273Read ↗

Genetic and molecular analysis of the Ah receptor and of Cyp1a1 gene expression.Semantic proximity Read ↗

Comparison of expression of aldehyde dehydrogenase 3 and CYP1A1 in dominant and recessive aryl hydrocarbon hydroxylase-deficient mutant mouse hepatoma cells.Semantic proximity Read ↗

Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription.Semantic proximity Read ↗

The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development.Semantic proximity Read ↗

The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology.Semantic proximity Read ↗

Identifying TCDD-resistance genes via murine and rat comparative genomics and transcriptomicsSemantic proximity Read ↗

Aberrant CYP1A1 induction: discrepancy of CYP1A1 mRNA and aryl hydrocarbon hydroxylase activity in mutant cells of mouse hepatoma line, Hepa-1.Semantic proximity Read ↗

Ah receptor regulation of mouse Cyp1B1 is additionally modulated by a second novel complex that forms at two AhR response elements.Semantic proximity Read ↗

A mutation in the aryl hydrocarbon receptor (AHR) in a cultured mammalian cell line identifies a novel region of AHR that affects DNA binding.Semantic proximity Read ↗

Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines.Semantic proximity Read ↗

Comparative microarray analysis of basal gene expression in mouse Hepa-1c1c7 wild-type and mutant cell lines.Semantic proximity Read ↗

Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.