Article
A genetic analysis of processes regulating cytochrome P4501A1 expression.
Advances in enzyme regulation - 1 Jan 1994
Hankinson O
Abstract excerpt
Cytochrome P4501A1 and its associated aryl hydrocarbon hydroxylase activity are highly inducible in the mouse hepatoma cell line, Hepa-1, by substrates of the enzyme and related compounds, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mutants of this cell line, deficient in P4501A1 inducibi...
Topics
- Animals
- Benzo(a)pyrene
- Cloning, Molecular
- Cytochrome P-450 CYP1A2
- Cytochromes
- Flow Cytometry
- Gene Expression Regulation, Enzymologic
- Genes
- Genetic Complementation Test
- Humans
- Mice
- Mutation
- Rats
- Receptors, Aryl Hydrocarbon
- Selection, Genetic
- Signal Transduction
- Transfection
- Tumor Cells, Cultured