Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.

doi:10.1074/jbc.R400004200

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Article

Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.

The Journal of biological chemistry - 4 Jun 2004

Nebert Daniel W, Dalton Timothy P, Okey Allan B, Gonzalez Frank J

Abstract excerpt

The mammalian CYP1A1, CYP1A2, and CYP1B1 genes (encoding cytochromes P450 1A1, 1A2, and 1B1, respectively) are regulated by the aromatic hydrocarbon receptor (AHR). The CYP1 enzymes are responsible for both metabolically activating and detoxifying numerous polycyclic aromatic hydrocarbons (PAHs) and aromatic amines present in combustion products. Many substrates for CYP1 enzymes are AHR ligands. Differences in...

Topics

Alleles
Animals
Carcinogens, Environmental
Cytochrome P-450 CYP1A1
Cytochrome P-450 Enzyme System
Cytosol
Dose-Response Relationship, Drug
Enzyme Induction
Humans
Kinetics
Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Mice

Mice, Transgenic

Neoplasms

Oxidative Stress

Placenta

Protein Binding

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Open in PubMed

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PMID: 15028720
DOI: 10.1074/jbc.R400004200

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