Article
Distal and proximal cis-linked sequences are needed for the total expression phenotype of the mouse alcohol dehydrogenase 1 (Adh1) gene.
Gene - 29 May 2002
Szalai Gabor, Xie Dong, Wassenich Michele, Veres Monika, Ceci Jeffrey D, Dewey Michael J, Molotkov Andrei, Duester Gregg, Felder Michael R
Abstract excerpt
Mouse alcohol dehydrogenase 1 (Adh1) gene expression occurs at high levels in liver and adrenal, moderate levels in kidney and intestine, low levels in a number of other tissues, and is undetectable in thymus, spleen and brain by Northern analysis. In transgenic mice, a minigene construct containing 10 kb of upstream and 1.5 kb of downstream flanking sequence directs expression in kidney, adrenal, lung,...
Topics
- 5' Flanking Region
- Alcohol Dehydrogenase
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Cosmids
- DNA
- Female
- Gene Expression Regulation, Enzymologic
- Male
- Mice
- Mice, Inbred C3H