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Article

Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.

Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 1999

Buters J T, Sakai S, Richter T, Pineau T, Alexander D L, Savas U, Doehmer J, Ward J M, Jefcoate C R, Gonzalez F J

Abstract excerpt

CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype, thus establishing that CYP1B1 is not required for mouse development. CYP1B1 was not detectable in cultured embryonic fibroblast (EF) or in different tissues, such as lung, of the CYP1B1-null mouse treated with the aryl hydrocarbon receptor...

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Identifiers

PMID: 10051580
DOI: 10.1073/pnas.96.5.1977
PMCID: PMC26722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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