Article
Genetic and molecular analysis of the Ah receptor and of Cyp1a1 gene expression.
Biochimie - 1 Jan 1991
Hankinson O, Brooks B A, Weir-Brown K I, Hoffman E C, Johnson B S, Nanthur J, Reyes H, Watson A J
Abstract excerpt
The Ah receptor is a soluble protein complex that mediates carcinogenesis by a wide range of environmental pollutants, including polycyclic aromatic hydrocarbons, heterocyclic amines, and polychlorinated aromatic compounds. The best understood activity of the receptor concerns its role in the induction of cytochrome P450IA1. We undertook a somatic cell genetic analysis of P450IA1 induction using the mouse...
Topics
- Animals
- Cloning, Molecular
- Cytochrome P-450 Enzyme System
- Gene Expression Regulation
- Genetic Complementation Test
- Mutation
- Receptors, Aryl Hydrocarbon
- Receptors, Drug
- Selection, Genetic
- Transfection
- Tumor Cells, Cultured