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Article

Expression and inducibility of P450 enzymes during liver ontogeny

1 Dec 1997

Abstract excerpt

Several approaches, including immunoquantification of individual enzymes, profiling of substrate activities by immunoinhibition using highly specific polyclonal and monoclonal antibodies, and the estimation of corresponding mRNAs with nucleic acid probes, have been used to investigate the ontogeny of cytochromes P450 in livers of rodents and man. CYP1A1 is expressed very early in development in rodents, whereas...

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PMID: 9408909
DOI: 10.1002/(sici)1097-0029(19971201)39:5<424::aid-jemt5>3.0.co;2-g

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