Restoration of fragile histidine triad ( <i>FHIT</i> ) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines

Abstract excerpt

Loss of expression of the Fhit protein is often associated with the development of many human epithelial cancers, including lung and cervical carcinomas. Restoration of Fhit expression in cell lines derived from these tumors has however yielded conflicting results, prompting the need for careful evaluation of the oncosuppressive potential of FHIT. In the present study, we have investigated the effect of Fhit...

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