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Article

Fhit deficiency-induced global genome instability promotes mutation and clonal expansion.

PloS one - 1 Jan 2013

Miuma Satoshi, Saldivar Joshua C, Karras Jenna R, Waters Catherine E, Paisie Carolyn A, Wang Yao, Jin Victor, Sun Jin, Druck Teresa, Zhang Jie, Huebner Kay

Abstract excerpt

Loss of Fhit expression, encoded at chromosome fragile site FRA3B, leads to increased replication stress, genome instability and accumulation of genetic alterations. We have proposed that Fhit is a genome 'caretaker' whose loss initiates genome instability in preneoplastic lesions. We have characterized allele copy number alterations and expression changes observed in Fhit-deficient cells in conjunction with...

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Identifiers

PMID: 24244712
DOI: 10.1371/journal.pone.0080730
PMCID: PMC3828255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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