Article
slo K(+) channel gene regulation mediates rapid drug tolerance.
Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 2004
Ghezzi Alfredo, Al-Hasan Yazan M, Larios Leo E, Bohm Rudolf A, Atkinson Nigel S
Abstract excerpt
Changes in neural activity caused by exposure to drugs may trigger homeostatic mechanisms that attempt to restore normal neural excitability. In Drosophila, a single sedation with the anesthetic benzyl alcohol changes the expression of the slo K(+) channel gene and induces rapid drug tolerance. We demonstrate linkage between these two phenomena by using a mutation and a transgene. A mutation that eliminates slo...
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