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Article

Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination.

Neuropharmacology - 1 Sept 2017

Blednov Yuri A, Borghese Cecilia M, Ruiz Carlos I, Cullins Madeline A, Da Costa Adriana, Osterndorff-Kahanek Elizabeth A, Homanics Gregg E, Harris R Adron

Abstract excerpt

Genes encoding the ρ1/2 subunits of GABAA receptors have been associated with alcohol (ethanol) dependence in humans, and ρ1 was also shown to regulate some of the behavioral effects of ethanol in animal models. Ethanol inhibits GABA-mediated responses in wild-type (WT) ρ1, but not ρ1(T6'Y) mutant receptors expressed in Xenopus laevis oocytes, indicating the presence of an inhibitory site for ethanol in the...

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Identifiers

PMID: 28623169
DOI: 10.1016/j.neuropharm.2017.06.013
PMCID: PMC5543808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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