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Article

Lipid environment modulates the development of acute tolerance to ethanol in Caenorhabditis elegans.

PloS one - 1 Jan 2012

Bettinger Jill C, Leung Kapo, Bolling Mia H, Goldsmith Andrew D, Davies Andrew G

Abstract excerpt

The development of tolerance to a drug at the level of the neuron reflects a homeostatic mechanism by which neurons respond to perturbations of their function by external stimuli. Acute functional tolerance (AFT) to ethanol is a fast compensatory response that develops within a single drug session and normalizes neuronal function despite the continued presence of the drug. We performed a genetic screen to...

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Identifiers

PMID: 22574115
DOI: 10.1371/journal.pone.0035192
PMCID: PMC3344825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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