Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tolerance to anesthesia depends on synaptic proteins.

Behavior genetics - 1 Sept 2011

Al-Hasan Yazan M, Krishnan Harish R, Ghezzi Alfredo, Prado Francisco J, Robles Roseanna B, Atkinson Nigel S

Abstract excerpt

The hypnotic effects of anesthetics are caused by their interactions with neuronal components vital for proper signaling. An understanding of the adaptive mechanisms that lead to the development of anesthetic tolerance can offer insight into the regulation of neuroexcitability and plasticity that alter behavioral output. Here we use genetic and pharmacological manipulation of Drosophila to investigate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthesia
Share to Anesthetics
Share to Drug Tolerance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophysiology

Share to Ethylmaleimide

Share to Substance-Related Disorders

Share to Synapses

Share to Synaptic Vesicles

Source

Open in PubMed Open full text

Identifiers

PMID: 21318409
DOI: 10.1007/s10519-011-9451-8
PMCID: PMC3163005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tolerance to anesthesia depends on synaptic proteins.PMID 21318409Read ↗

A role for dynamin in triggering ethanol tolerance.Semantic proximity Read ↗

slo K(+) channel gene regulation mediates rapid drug tolerance.Semantic proximity Read ↗

Alleviation of the temperature-sensitive paralytic phenotype of shibire(ts) mutants in Drosophila by sub-anesthetic concentrations of carbon dioxide.Semantic proximity Read ↗

The slowpoke gene is necessary for rapid ethanol tolerance in Drosophila.Semantic proximity Read ↗

Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination.Semantic proximity Read ↗

Isoflurane reduces excitability of Drosophila larval motoneurons by activating a hyperpolarizing leak conductance.Semantic proximity Read ↗

Functional ethanol tolerance in Drosophila.Semantic proximity Read ↗

Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila.Semantic proximity Read ↗

Acquired temperature-sensitive paralysis as a biomarker of declining neuronal function in aging Drosophila.Semantic proximity Read ↗

Optical reversal of halothane-induced immobility in C. elegans.Semantic proximity Read ↗

Anesthetics Have Different Effects on the Electrocorticographic Spectra of Wild-type and Mitochondrial Mutant Mice.Semantic proximity Read ↗

Genetic modifiers of comatose mutations in Drosophila: insights into neuronal NSF (N-ethylmaleimide-sensitive fusion factor) functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.