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Article

CREB regulation of BK channel gene expression underlies rapid drug tolerance.

Genes, brain, and behavior - 1 Jun 2009

Wang Y, Ghezzi A, Yin J C P, Atkinson N S

Abstract excerpt

Pharmacodynamic tolerance is believed to involve homeostatic mechanisms initiated to restore normal neural function. Drosophila exposed to a sedating dose of an organic solvent, such as benzyl alcohol or ethanol, acquire tolerance to subsequent sedation by that solvent. The slo gene encodes BK-type Ca(2+)-activated K(+) channels and has been linked to alcohol- and organic solvent-induced behavioral tolerance in...

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Identifiers

PMID: 19243452
DOI: 10.1111/j.1601-183X.2009.00479.x
PMCID: PMC2796570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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