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Article

Large analysis of genetic manipulations reveals an inverse correlation between initial alcohol resistance and rapid tolerance phenotypes.

Genes, brain, and behavior - 1 Feb 2024

Chvilicek Maggie M, Seguin Alexandra, Lathen Daniel R, Titos Iris, Cummins-Beebee Pearl N, Pabon Miguel A, Miščević Maša, Nickel Emily, Merrill Collin B, Rodan Aylin R, Rothenfluh Adrian

Abstract excerpt

Tolerance occurs when, following an initial experience with a substance, more of the substance is required subsequently to induce identical behavioral effects. Tolerance is not well-understood, and numerous researchers have turned to model organisms, particularly Drosophila melanogaster, to unravel its mechanisms. Flies have high translational relevance for human alcohol responses, and there is substantial...

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PMID: 38968320
DOI: 10.1111/gbb.12884
PMCID: PMC10825885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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