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Article

Restricted inactivation of serum response factor to the cardiovascular system.

Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 2004

Miano Joseph M, Ramanan Narendrakumar, Georger Mary A, de Mesy Bentley Karen L, Emerson Rachael L, Balza Robert O, Xiao Qi, Weiler Hartmut, Ginty David D, Misra Ravi P

Abstract excerpt

Serum response factor (SRF) directs programs of gene expression linked to growth and muscle differentiation. To investigate the role of SRF in cardiovascular development, we generated mice in which SRF is knocked out in >80% of cardiomyocytes and >50% of vascular smooth muscle cells (SMC) through SM22alpha-Cre-mediated excision of SRF's promoter and first exon. Mutant mice display vascular patterning, cardiac...

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Source

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Identifiers

PMID: 15569937
DOI: 10.1073/pnas.0406041101
PMCID: PMC535359

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Restricted inactivation of serum response factor to the cardiovascular system.PMID 15569937Read ↗

Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes.Semantic proximity Read ↗

Endothelial-specific ablation of serum response factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality.Semantic proximity Read ↗

The serum response factor coactivator myocardin is required for vascular smooth muscle development.Semantic proximity Read ↗

Early postnatal cardiac changes and premature death in transgenic mice overexpressing a mutant form of serum response factor.Semantic proximity Read ↗

Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression.Semantic proximity Read ↗

Mosaic inactivation of the serum response factor gene in the myocardium induces focal lesions and heart failure.Semantic proximity Read ↗

Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development.Semantic proximity Read ↗

Mural cell SRF controls pericyte migration, vessel patterning and blood flowSemantic proximity Read ↗

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytesSemantic proximity Read ↗

SRF: a seriously responsible factor in cardiac development and diseaseSemantic proximity Read ↗

Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation.Semantic proximity Read ↗

A serum response factor-dependent transcriptional regulatory program identifies distinct smooth muscle cell sublineages.Semantic proximity Read ↗

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