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Article

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes

26 Feb 2011

Abstract excerpt

Myocardin is a serum response factor (SRF) coactivator exclusively expressed in cardiomyocytes and smooth muscle cells (SMCs). However, there is highly controversial evidence as to whether myocardin is essential for normal differentiation of these cell types, and there are no data showing whether cardiac or SMC subtypes exhibit differential myocardin requirements during development. Results of the present studies...

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Identifiers

PMID: 21357509
DOI: 10.1152/ajpheart.01192.2010

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Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytesPMID 21357509Read ↗

Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development.Semantic proximity Read ↗

The serum response factor coactivator myocardin is required for vascular smooth muscle development.Semantic proximity Read ↗

Myocardin is required for cardiomyocyte survival and maintenance of heart functionSemantic proximity Read ↗

Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression.Semantic proximity Read ↗

Myocardin overexpression is sufficient for promoting the development of a mature smooth muscle cell-like phenotype from human embryonic stem cells.Semantic proximity Read ↗

Myocardin-related transcription factors are required for cardiac development and functionSemantic proximity Read ↗

Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice.Semantic proximity Read ↗

Myocardin is sufficient and necessary for cardiac gene expression in Xenopus.Semantic proximity Read ↗

Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression.Semantic proximity Read ↗

miR-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development.Semantic proximity Read ↗

Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation.Semantic proximity Read ↗

Importance of Myocyte-Nonmyocyte Interactions in Cardiac Development and DiseaseSemantic proximity Read ↗

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