Article
Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development.
Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2015
Huang Jianhe, Wang Tao, Wright Alexander C, Yang Jifu, Zhou Su, Li Li, Yang Jisheng, Small Aeron, Parmacek Michael S
Abstract excerpt
Myocardin is a muscle-restricted transcriptional coactivator that activates a serum response factor (SRF)-dependent gene program required for cardiogenesis and embryonic survival. To identify myocardin-dependent functions in smooth muscle cells (SMCs) during postnatal development, mice harboring a SMC-restricted conditional, inducible Myocd null mutation were generated and characterized. Tamoxifen-treated...
Topics
- Animals
- Aorta
- Aortic Aneurysm
- Apoptosis
- Autophagy
- Gastrointestinal Tract
- Gene Expression Regulation, Developmental
- Homeostasis
- Mice
- Mice, Transgenic
- Muscle Contraction
- Muscle, Smooth, Vascular
- Mutation