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Article

Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation.

Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2005

Oh Jiyeon, Richardson James A, Olson Eric N

Abstract excerpt

Myocardin and the myocardin-related transcription factors (MRTFs) A and B act as coactivators for serum response factor, which plays a key role in cardiovascular development. To determine the functions of MRTF-B in vivo, we generated MRTF-B mutant mice by targeted inactivation of the MRTF-B gene. We show that mice homozygous for an MRTF-B loss-of-function mutation die during mid-gestation from a spectrum of...

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Share to Arteries
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cardiovascular Abnormalities

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Source

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Identifiers

PMID: 16204380
DOI: 10.1073/pnas.0507346102
PMCID: PMC1257726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation.PMID 16204380Read ↗

Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression.Semantic proximity Read ↗

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Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytesSemantic proximity Read ↗

Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression.Semantic proximity Read ↗

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Myocardin-related transcription factors are required for cardiac development and functionSemantic proximity Read ↗

Myocardin is sufficient and necessary for cardiac gene expression in Xenopus.Semantic proximity Read ↗

Restricted inactivation of serum response factor to the cardiovascular system.Semantic proximity Read ↗

miR-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development.Semantic proximity Read ↗

The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression.Semantic proximity Read ↗

Myocardin is a master regulator of smooth muscle gene expression.Semantic proximity Read ↗

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