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Article

Endothelial-specific ablation of serum response factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality.

BMC developmental biology - 20 Jun 2008

Holtz Mary L, Misra Ravi P

Abstract excerpt

BACKGROUND: Serum response factor (SRF), a member of the MADS box family of nuclear transcription factors, plays an important role in cardiovascular development and function. Numerous studies demonstrate a central role for SRF in regulating smooth and cardiac muscle cell gene expression. Consistent with this, loss of SRF function blocks differentiation of coronary vascular smooth muscle cells from proepicardial...

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Topics

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Share to Embryo, Mammalian
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18570667
DOI: 10.1186/1471-213X-8-65
PMCID: PMC2442838

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Endothelial-specific ablation of serum response factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality.PMID 18570667Read ↗

Restricted inactivation of serum response factor to the cardiovascular system.Semantic proximity Read ↗

Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae.Semantic proximity Read ↗

The serum response factor coactivator myocardin is required for vascular smooth muscle development.Semantic proximity Read ↗

Mutant-specific gene expression profiling identifies SRY-related HMG box 11b (SOX11b) as a novel regulator of vascular development in zebrafish.Semantic proximity Read ↗

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodelingSemantic proximity Read ↗

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.Semantic proximity Read ↗

Mural cell SRF controls pericyte migration, vessel patterning and blood flowSemantic proximity Read ↗

Angiopoietin-1 is essential in mouse vasculature during development and in response to injurySemantic proximity Read ↗

<i>Crk/Crkl</i> regulates early angiogenesis in mouse embryos by accelerating endothelial cell maturationSemantic proximity Read ↗

Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tractSemantic proximity Read ↗

Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development.Semantic proximity Read ↗

SRF: a seriously responsible factor in cardiac development and diseaseSemantic proximity Read ↗

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