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Article

Mosaic inactivation of the serum response factor gene in the myocardium induces focal lesions and heart failure.

European journal of heart failure - 1 Jul 2008

Gary-Bobo Guillaume, Parlakian Ara, Escoubet Brigitte, Franco Claudio Areias, Clément Sophie, Bruneval Patrick, Tuil David, Daegelen Dominique, Paulin Denise, Li Zhenlin, Mericskay Mathias

Abstract excerpt

BACKGROUND AND AIMS: Regional alterations in ventricular mechanical functions are a primary determinant for the risk of myocardial injuries in various cardiomyopathies. The serum response factor (SRF) is a transcription factor regulating contractile and cytoskeletal genes and may play an important role in the remodelling of myocardium at the cellular level. METHODS: Using Desmin-Cre transgenic mice, we generated...

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Source

Identifiers

PMID: 18501668
DOI: 10.1016/j.ejheart.2008.04.014

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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