Article
Polymorphism in plasmodium falciparum drug transporter proteins and reversal of in vitro chloroquine resistance by a 9,10-dihydroethanoanthracene derivative.
Antimicrobial agents and chemotherapy - 1 Dec 2004
Millet Julie, Alibert Sandrine, Torrentino-Madamet Marylin, Rogier Christophe, Santelli-Rouvier Christiane, Bigot Patricia, Mosnier Joel, Baret Eric, Barbe Jacques, Parzy Daniel, Pradines Bruno
Abstract excerpt
BG958 reverses resistance in chloroquine-resistant isolates from different countries. Five mutations in the Plasmodium falciparum crt (pfcrt) gene resulting in the amino acid changes K76T, M74I, N75E, A220S, and R371I are systematically identified in resistance-reversed Asian, African, and Brazilian parasites which possess the pfcrt (CIET) haplotype. In combination with BG958, the activity of chloroquine is...
Topics
- Animals
- Anthracenes
- Antimalarials
- Carrier Proteins
- Chloroquine
- DNA, Protozoan
- Drug Resistance
- Drug Synergism
- Genes, MDR
- Humans