High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1.

doi:10.1086/320195

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Article

High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1.

The Journal of infectious diseases - 15 May 2001

Babiker H A, Pringle S J, Abdel-Muhsin A, Mackinnon M, Hunt P, Walliker D

Abstract excerpt

Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance gene pfmdr1-Y86 allele. A...

Topics

ATP-Binding Cassette Transporters
Alleles
Animals
Antimalarials
Chloroquine
Clone Cells
Drug Resistance
Genes, Protozoan
Humans
Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Malaria, Falciparum

Membrane Proteins

Membrane Transport Proteins

Mutation

Parasitic Sensitivity Tests

Plasmodium falciparum

Polymorphism, Genetic

Protozoan Proteins

Source

Open in PubMed

Identifiers

PMID: 11319692
DOI: 10.1086/320195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11319692-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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