Article
Genome-wide compensatory changes accompany drug- selected mutations in the Plasmodium falciparum crt gene.
PloS one - 25 Jun 2008
Jiang Hongying, Patel Jigar J, Yi Ming, Mu Jianbing, Ding Jinhui, Stephens Robert, Cooper Roland A, Ferdig Michael T, Su Xin-zhuan
Abstract excerpt
Mutations in PfCRT (Plasmodium falciparum chloroquine-resistant transporter), particularly the substitution at amino acid position 76, confer chloroquine (CQ) resistance in P. falciparum. Point mutations in the homolog of the mammalian multidrug resistance gene (pfmdr1) can also modulate the levels of CQ response. Moreover, parasites with the same pfcrt and pfmdr1 alleles exhibit a wide range of drug sensitivity,...
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