Article
Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.
Science (New York, N.Y.) - 4 Oct 2002
Sidhu Amar Bir Singh, Verdier-Pinard Dominik, Fidock David A
Abstract excerpt
Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance. Here, we provide conclusive evidence that...
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