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Article

A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

The EMBO journal - 6 Jul 2005

Lakshmanan Viswanathan, Bray Patrick G, Verdier-Pinard Dominik, Johnson David J, Horrocks Paul, Muhle Rebecca A, Alakpa George E, Hughes Ruth H, Ward Steve A, Krogstad Donald J, Sidhu Amar Bir Singh, Fidock David A

Abstract excerpt

Chloroquine resistance (CQR) in Plasmodium falciparum is associated with mutations in the digestive vacuole transmembrane protein PfCRT. However, the contribution of individual pfcrt mutations has not been clarified and other genes have been postulated to play a substantial role. Using allelic ex...

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Identifiers

PMID: 15944738
DOI: 10.1038/sj.emboj.7600681
PMCID: PMC1173140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15944738-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.PMID 15944738Read ↗

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