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Article

Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum.

Malaria journal - 15 Feb 2011

Chaijaroenkul Wanna, Ward Stephen A, Mungthin Mathirut, Johnson David, Owen Andrew, Bray Patrick G, Na-Bangchang Kesara

Abstract excerpt

BACKGROUND: Plasmodium falciparum chloroquine resistance (CQR) transporter protein (PfCRT) is known to be the important key of CQR. Recent studies have definitively demonstrated a link between mutations in the gene pfcrt and resistance to chloroquine in P. falciparum. Although these mutations are predictive of chloroquine resistance, they are not quantitatively predictive of the degree of resistance. METHODS: In...

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Identifiers

PMID: 21320353
DOI: 10.1186/1475-2875-10-42
PMCID: PMC3055224

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