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Article

Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.

Journal of cell science - 15 Dec 2004

Tighe Anthony, Johnson Victoria L, Taylor Stephen S

Abstract excerpt

The majority of human tumour cells are aneuploid owing to an underlying chromosome instability phenotype. While the genetic lesions that cause chromosome instability remain undefined, mouse ES cells harbouring homozygous adenomatous polyposis coli (APC) mutations are frequently tetraploid. In addition, colon cancer cells with APC mutations have weakened kinetochore-microtubule interactions. Furthermore, mitotic...

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Source

Identifiers

PMID: 15561772
DOI: 10.1242/jcs.01556

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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