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Article

APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation.

Gastroenterology - 1 Jun 2007

Abal Miguel, Obrador-Hevia Antonia, Janssen Klaus-Peter, Casadome Laura, Menendez Mireia, Carpentier Sabrina, Barillot Emmanuel, Wagner Mechthild, Ansorge Wilhelm, Moeslein Gabriela, Fsihi Hafida, Bezrookove Vladimir, Reventos Jaume, Louvard Daniel, Capella Gabriel, Robine Sylvie

Abstract excerpt

BACKGROUND & AIMS: Chromosomal instability, a hallmark of most colorectal cancers, has been related to altered chromosome segregation and the consequent deficit in genetic integrity. A role for the tumor suppressor gene APC has been proposed in colorectal cancer that leads to compromised chromosome segregation even though the molecular mechanism is not yet understood. Here, we tackled the genetic basis for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17570218
DOI: 10.1053/j.gastro.2007.03.027

Genes

APC

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