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PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells

12 Mar 2018

Abstract excerpt

Abstract The spindle assembly checkpoint (SAC) acts as a molecular safeguard in ensuring faithful chromosome transmission during mitosis, which is regulated by a complex interplay between phosphatases and kinases including PLK1. Adenomatous polyposis coli (APC) germline mutations cause aneuploidy and are responsible for familial adenomatous polyposis (FAP). Here we study the role of PLK1 in colon cancer cells...

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PMID: 29549256
DOI: 10.1038/s41467-018-03494-4

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