Article
Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli.
Oncogene - 21 Aug 2008
Kouzmenko A P, Takeyama K, Kawasaki Y, Akiyama T, Kato S
Abstract excerpt
The adenomatous polyposis coli (APC) is a tumor suppressor whose loss of function leads to colon cancer. APC shuttles between the nucleus and cytoplasm, however its role in the nucleus remains elusive. We have found that nuclear APC specifically associates with transcriptionally active chromatin through structural elements located downstream to the region of frequent truncation mutations found in colorectal...
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