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Article

APC shuttling to the membrane, nucleus and beyond.

Trends in cell biology - 1 Dec 2008

Brocardo Mariana, Henderson Beric R

Abstract excerpt

The adenomatous polyposis coli (APC) tumor suppressor is a multi-functional protein, the mutation of which triggers colon cancer progression through de-regulation of the canonical Wnt signaling pathway and disruption of the mitotic spindle checkpoint. In recent years, APC has been detected at several unexpected intracellular locations, implicating APC in multiple roles that now include the regulation of directed...

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Topics

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Share to Adenomatous Polyposis Coli Protein
Share to Cell Movement
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18848448
DOI: 10.1016/j.tcb.2008.09.002

Genes

APC
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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