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Article

APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice.

The Journal of cell biology - 24 Sept 2007

Caldwell Christine M, Green Rebecca A, Kaplan Kenneth B

Abstract excerpt

Previous research has proposed that genomic instability contributes to cancer progression, with its initiation linked to tetraploid cell formation (Duesberg, P., and R. Li. 2003. Cell Cycle. 2:202-210; Ganem, N.J., Z. Storchova, and D. Pellman. 2007. Curr. Opin. Genet. Dev. 17:157-162). However,...

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Share to Adenomatous Polyposis Coli
Share to Cytokinesis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Mutant Strains

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Source

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Identifiers

PMID: 17893240
DOI: 10.1083/jcb.200703186
PMCID: PMC2064647

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17893240-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice.PMID 17893240Read ↗

Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability.Semantic proximity Read ↗

APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation.Semantic proximity Read ↗

Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.Semantic proximity Read ↗

Intestinal adenomas can develop with a stable karyotype and stable microsatellitesSemantic proximity Read ↗

Spindle Microtubule Dysfunction and Cancer PredispositionSemantic proximity Read ↗

Aberrant Wnt/β-catenin signaling can induce chromosomal instability in colon cancerSemantic proximity Read ↗

High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiationSemantic proximity Read ↗

PLK1 has tumor-suppressive potential in APC-truncated colon cancer cellsSemantic proximity Read ↗

Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice.Semantic proximity Read ↗

Survivin-induced Aurora-B kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development.Semantic proximity Read ↗

Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.Semantic proximity Read ↗

Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC.Semantic proximity Read ↗

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