Article
Somatic mutation during metastasis of a mouse fibrosarcoma line detected by DNA fingerprint analysis.
Japanese journal of cancer research : Gann - 1 Feb 1992
Takada T, Suzuki S, Sugawara Y, Kominami R, Arakawa M, Niwa O, Yokoro K
Abstract excerpt
Metastatic nodules were examined by DNA fingerprint analysis. The probes used, Pc-1 and Pc-2, detect mutations as shifts in bands of the minisatellite loci which are dispersed among chromosomes. Four clonal lines of a fibrosarcoma from an F1 mouse (C57BL/Ka x C3H/He) were selected for various metastatic potentials upon inoculation into syngeneic mice. These four lines exhibited many extra bands resulting from...
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