Acquisition and enhanced expression of the metastatic phenotype following transfections of genomic mouse tumor DNA containing human SCLC gene sequences.

doi:10.1007/BF00132209

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Article

Acquisition and enhanced expression of the metastatic phenotype following transfections of genomic mouse tumor DNA containing human SCLC gene sequences.

Clinical & experimental metastasis - 1 May 1995

Cate C C, Belloni D R, Marin-Padilla M

Abstract excerpt

Previous primary and secondary co-transfections of genomic DNA from a metastatic human small cell lung cancer cell line into NIH/3T3 cells resulted in a murine fibrosarcoma cell line (Tx93B) that produced frequent spontaneous lung metastases in subcutaneously injected tumor-bearing nude mice. In order to transfer the acquired metastatic behavior to additional cell lines that could then be tested in syngeneic...

Topics

3T3 Cells
Animals
Base Sequence
Carcinoma, Small Cell
Cell Division
DNA, Neoplasm
Female
Genome
Genome, Human
Humans
Lung Neoplasms
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Nude

Neoplasm Metastasis

Phenotype

Transfection

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7750208
DOI: 10.1007/BF00132209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7750208-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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