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Article

P53 gene deficiency does not enhance instability of mouse minisatellites in somatic cells of normal tissues.

Japanese journal of cancer research : Gann - 1 Jul 1996

Ohashi M, Hatakeyama K, Aizawa S, Kominami R

Abstract excerpt

The effect of p53-deficiency on somatic mutation of minisatellites in normal tissues was examined using p53-deficient (-/-) mice. In total, 248 mice consisting of three different genotypes, +/+, +/ -and -/-, were obtained and DNA from their embryos was probed with two minisatellites, Pc-1 and Pc-2. The somatic mutation was detected by Southern blot hybridization as the presence of a third nonparental band...

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Identifiers

PMID: 8698618
DOI: 10.1111/j.1349-7006.1996.tb00280.x
PMCID: PMC5921163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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