P53 gene deficiency does not enhance instability of mouse minisatellites in somatic cells of normal tissues.

doi:10.1111/j.1349-7006.1996.tb00280.x

Back to search

Article

P53 gene deficiency does not enhance instability of mouse minisatellites in somatic cells of normal tissues.

Japanese journal of cancer research : Gann - 1 Jul 1996

Ohashi M, Hatakeyama K, Aizawa S, Kominami R

Abstract excerpt

The effect of p53-deficiency on somatic mutation of minisatellites in normal tissues was examined using p53-deficient (-/-) mice. In total, 248 mice consisting of three different genotypes, +/+, +/ -and -/-, were obtained and DNA from their embryos was probed with two minisatellites, Pc-1 and Pc-...

Topics

Animals
Base Sequence
Female
Genes, p53
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Knockout
Microsatellite Repeats
Molecular Sequence Data
Mutation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.