Article
The role of multiple somatic point mutations in metastatic progression.
Mathematical biosciences - 1 Feb 1992
Kendal W S
Abstract excerpt
To test the hypothesis that the ability to metastasize is determined by multiple point mutations during the expansion of a neoplastic clone, a mathematical model for sequential mutations was derived. Development of the metastatic phenotype was attributed to the mutation of a specific group of genes. The average tumor size was estimated for when a cell should manifest a set number of these mutated genes. In a...
Topics
- Animals
- Genetic Variation
- Humans
- Mathematics
- Models, Biological
- Mutation
- Neoplasm Metastasis
- Neoplasms