Increased spontaneous mutation rates and prevalence of karyotype abnormalities in highly metastatic human melanoma cell lines.

doi:10.1097/00008390-199304000-00008

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Article

Increased spontaneous mutation rates and prevalence of karyotype abnormalities in highly metastatic human melanoma cell lines.

Melanoma research - 1 Feb 1993

Bailly M, Bertrand S, Doré J F

Abstract excerpt

Previous studies have suggested that increased malignant potential might be related to increased genomic instability, but this issue still remains controversial. We tested this hypothesis in a human tumour spontaneous metastasis model, using six clones and variants isolated from the parental poor...

Topics

Cell Division
Chromosome Aberrations
Chromosome Disorders
Clone Cells
Drug Resistance
Genetic Variation
Humans
Karyotyping
Melanoma
Mutation
Neoplasm Metastasis
Ouabain
Tumor Cells, Cultured

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