Increased spontaneous mutation rates and prevalence of karyotype abnormalities in highly metastatic human melanoma cell lines.

Abstract excerpt

Previous studies have suggested that increased malignant potential might be related to increased genomic instability, but this issue still remains controversial. We tested this hypothesis in a human tumour spontaneous metastasis model, using six clones and variants isolated from the parental poorly metastatic M4Be melanoma cell line, and expressing various metastatic abilities. The spontaneous rates of mutation...

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