Human minisatellite MS32 (D1S8) displays somatic but not germline instability in transgenic mice.

doi:10.1093/hmg/6.9.1565

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Article

Human minisatellite MS32 (D1S8) displays somatic but not germline instability in transgenic mice.

Human molecular genetics - 1 Sept 1997

Bois P, Collick A, Brown J, Jeffreys A J

Abstract excerpt

Human minisatellite MS32 (D1S8) shows instability both in the germline and, at much lower levels, in somatic DNA. To investigate factors that influence somatic and germline mutation, large cosmid-based constructs containing MS32 were introduced into mice, bred to homozygosity and tested for insta...

Topics

Alleles
Animals
Gene Rearrangement
Germ-Line Mutation
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Transgenic
Minisatellite Repeats
Polymerase Chain Reaction
Transgenes

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