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Article

Linkage analysis in the presence of errors II: marker-locus genotyping errors modeled with hypercomplex recombination fractions.

American journal of human genetics - 1 Mar 2000

Göring H H, Terwilliger J D

Abstract excerpt

It is well known that genotyping errors lead to loss of power in gene-mapping studies and underestimation of the strength of correlations between trait- and marker-locus genotypes. In two-point linkage analysis, these errors can be absorbed in an inflated recombination-fraction estimate, leaving the test statistic quite robust. In multipoint analysis, however, genotyping errors can easily result in false...

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PMID: 10712221
DOI: 10.1086/302798
PMCID: PMC1288145

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