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Article

Linkage analysis in the presence of errors I: complex-valued recombination fractions and complex phenotypes.

American journal of human genetics - 1 Mar 2000

Göring H H, Terwilliger J D

Abstract excerpt

Linkage is a phenomenon that correlates the genotypes of loci, rather than the phenotypes of one locus to the genotypes of another. It is therefore necessary to convert the observed trait phenotypes into trait-locus genotypes, which can then be analyzed for coinheritance with marker-locus genotypes. However, if the mode of inheritance of the trait is not known accurately, this conversion can often result in...

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PMID: 10712220
DOI: 10.1086/302797
PMCID: PMC1288144

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