Using linkage analysis to detect gene-gene interaction by stratifying family data on known disease, or disease-associated, alleles.

Abstract excerpt

Detecting gene-gene interaction in complex diseases is a major challenge for common disease genetics. Most interaction detection approaches use disease-marker associations and such methods have low power and unknown reliability in real data. We developed and tested a powerful linkage-analysis-based gene-gene interaction detection strategy based on conditioning the family data on a known disease-causing allele or...

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