Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2004

Hessner Martin J, Wang Xujing, Meyer Lisa, Geoffrey Rhonda, Jia Shuang, Fuller Jessica, Lernmark Ake, Ghosh Soumitra

Abstract excerpt

Allergy and autoimmunity are both examples of deregulated immunity characterized by inflammation and injury of targeted tissues that have until recently been considered disparate disease processes. However, recent findings have implicated mast cells, in coordination with granulocytes and other immune effector cells, in the pathology of these two disorders. The BioBreeding (BB) DRlyp/lyp rat develops an autoimmune...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokines, CC
Share to Eosinophils

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mast Cells

Share to Prediabetic State

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Rats, Inbred BB

Share to Receptors, IgE

Source

Identifiers

PMID: 15557196
DOI: 10.4049/jimmunol.173.11.6993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat.PMID 15557196Read ↗

Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat.Semantic proximity Read ↗

Iddm30 controls pancreatic expression of Ccl11 (Eotaxin) and the Th1/Th2 balance within the insulitic lesions.Semantic proximity Read ↗

Type 1 Diabetes in the BB Rat: A Polygenic DiseaseSemantic proximity Read ↗

Rel B is an early marker of autoimmune islet inflammation in the biobreeding (BB) rat.Semantic proximity Read ↗

BB rat <i>lyp</i> mutation and Type 1 diabetesSemantic proximity Read ↗

Lessons on autoimmune diabetes from animal models.Semantic proximity Read ↗

A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.Semantic proximity Read ↗

Genetic dissection of Iddm26 in the spontaneously diabetic BBDP rat.Semantic proximity Read ↗

Type 1 diabetes in BioBreeding rats is critically linked to an imbalance between Th17 and regulatory T cells and an altered TCR repertoire.Semantic proximity Read ↗

TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints.Semantic proximity Read ↗

Wheat protein-induced proinflammatory T helper 1 bias in mesenteric lymph nodes of young diabetes-prone rats.Semantic proximity Read ↗

Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.