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Article

BB rat <i>lyp</i> mutation and Type 1 diabetes

1 Dec 2001

Abstract excerpt

BioBreeding (BB) rats spontaneously develop an autoimmune diabetic syndrome similar to that observed in humans and NOD mice. One of the diabetes susceptibility loci maps to the lyp locus on chromosome 4. In this article we describe the consequences of the BB rat lyp mutation on T-cell homeostasis, repertoire and function, as well as its role in the pathogenesis of type I diabetes.

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Share to Diabetes and associated disorders
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Identifiers

PMID: 12086310
DOI: 10.1034/j.1600-065x.2001.1840115.x

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Related research

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Research trail→

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BB rat <i>lyp</i> mutation and Type 1 diabetesPMID 12086310Read ↗

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