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Article

Type 1 diabetes in BioBreeding rats is critically linked to an imbalance between Th17 and regulatory T cells and an altered TCR repertoire.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2010

van den Brandt Jens, Fischer Henrike J, Walter Lutz, Hünig Thomas, Klöting Ingrid, Reichardt Holger M

Abstract excerpt

Diabetes-prone BioBreeding (DP-BB) rats spontaneously develop type 1 diabetes mellitus (T1DM) on grounds of their MHC haplotype RT1(u) and a point mutation in the Gimap5 gene. In this study, we report that DP-BB rats exhibit an increasingly severe imbalance, in particular between Th17 and regulat...

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Source

Identifiers

PMID: 20644174
DOI: 10.4049/jimmunol.1000462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20644174-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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