Article
Lessons on autoimmune diabetes from animal models.
Clinical science (London, England : 1979) - 1 Jun 2006
Yang Yang, Santamaria Pere
Abstract excerpt
T1DM (Type I diabetes mellitus) results from selective destruction of the insulin-producing beta-cells of the pancreas by the immune system, and is characterized by hyperglycaemia and vascular complications arising from suboptimal control of blood glucose levels. The discovery of animal models of T1DM in the late 1970s and early 1980s, particularly the NOD (non-obese diabetic) mouse and the BB (BioBreeding)...
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